Validation of a novel high-sensitivity cardiac troponin assay

Abstract Background The accuracy for early identification of non-ST-elevation myocardial infarction (NSTEMI) in the emergency department must be determined all novel high-sensitivity cardiac troponin assays (hs-cTn). In this prospective, multi-centre study we developed rule-out algorithms a I (hs-cTnI) assay and compared it to established hs-cTnT hs-cTnI. Methods Two NSTEMI were from derivation cohort 977 patients assessed by Siemens Atellica IM hs-cTnI assay. Diagnostic performance was with (Roche) (Abbott) algorithms. derived tested two different validation cohorts (n=518 n=405, respectively). Results An admission sample algorithm (hs-cTnI (Siemens)) cutoff <5 ng/L had negative predictive value (NPV) 99.4–100.0%, sensitivity 98.3–100% specificity 46.7–56.5% cohorts. Sensitivity NPV similar, trended towards improvement over comparator (Figure 1). A 0–1 hour <10 Δ change <3 achieved 100% >70% both cohorts, similar (Table Conclusions Rule-out has comparable diagnostic hs-cTn Funding Acknowledgement Type funding sources: Public grant(s) – National budget only. Main source(s): grant: Western Norway Regional Health Authority.Private company funding: Healthineers AG